Current Projects
- Role of sphingomyelin and its metabolites in increased vulnerability to oxidative stress in aging assessed in cell lines and in synaptosomes isolated from rodents
- Neurotransmitter receptor properties that decrease resistance to oxidative stress and may account for the regional specificity of neuronal decline in aging
- Signaling properties in kinase cascades and subsequent activation of transcription factors in cells exposed to oxidative stress and antioxidants
- Role of monoamine oxidases in cellular dopamine toxicity
- Effects of reduction of endogenous antioxidants, such as glutathione and dopamine exposure, on cognitive and motor behavior in the rodent
- Effects of radiation- or oxygen-induced oxidative stress on accelerated brain aging and its retardation via intake of diets high in antioxidant fruits and vegetables
- Influence of diets high in antioxidant fruits and vegetables on the retardation and reversal of age-related declines in motor and cognitive function, G protein- mediated signal transduction, and calcium regulation
- Biophysical-lipid membrane interactions in aging and following oxidative stress
- Oxidative stress effects on receptor internalization
- Role of neuronal stimulation in subsequent protection against oxidative stress in cells